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External WebsitesDirector, Chemistry Division, Argonne National Laboratory, Argonne, Illinois, 1982–88; Section Head, Nuclear and Inorganic Chemistry, 1974–82.
Ellis P. Steinberg , John O. RasmussenEmeritus Professor of Chemistry, University of California, Berkeley. Author of "Models of Heavy Nuclei" in Nuclear Spectroscopy and others.
John O. Rasmussen • All Fact-checked by The Editors of Encyclopaedia BritannicaEncyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree. They write new content and verify and edit content received from contributors.
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Radioisotopes have found extensive use in diagnosis and therapy, and this has given rise to a rapidly growing field called nuclear medicine. These radioactive isotopes have proven particularly effective as tracers in certain diagnostic procedures. As radioisotopes are identical chemically with stable isotopes of the same element, they can take the place of the latter in physiological processes. Moreover, because of their radioactivity, they can be readily traced even in minute quantities with such detection devices as gamma-ray spectrometers and proportional counters. Though many radioisotopes are used as tracers, iodine-131, phosphorus-32, and technetium-99m are among the most important. Physicians employ iodine-131 to determine cardiac output, plasma volume, and fat metabolism and particularly to measure the activity of the thyroid gland where this isotope accumulates. Phosphorus-32 is useful in the identification of malignant tumours because cancerous cells tend to accumulate phosphates more than normal cells do. Technetium-99m, used with radiographic scanning devices, is valuable for studying the anatomic structure of organs.
Such radioisotopes as cobalt-60 and cesium-137 are widely used to treat cancer. They can be administered selectively to malignant tumours and so minimize damage to adjacent healthy tissue.
Foremost among industrial applications is power generation based on the release of the fission energy of uranium (see nuclear fission; nuclear reactor: Nuclear fission reactors). Other applications include the use of radioisotopes to measure (and control) the thickness or density of metal and plastic sheets, to stimulate the cross-linking of polymers, to induce mutations in plants in order to develop hardier species, and to preserve certain kinds of foods by killing microorganisms that cause spoilage. In tracer applications radioactive isotopes are employed, for example, to measure the effectiveness of motor oils on the wearability of alloys for piston rings and cylinder walls in automobile engines. For additional information about industrial uses, see radiation: Applications in science and industry.
Research in the Earth sciences has benefited greatly from the use of radiometric-dating techniques, which are based on the principle that a particular radioisotope (radioactive parent) in geologic material decays at a constant known rate to daughter isotopes. Using such techniques, investigators have been able to determine the ages of various rocks and rock formations and thereby quantify the geologic time scale (see geochronology: Absolute dating). A special application of this type of radioactivity age method, carbon-14 dating, has proved especially useful to physical anthropologists and archaeologists. It has helped them to better determine the chronological sequence of past events by enabling them to date more accurately fossils and artifacts from 500 to 50,000 years old.
Radioisotopic tracers are employed in environmental studies, as, for instance, those of water pollution in rivers and lakes and of air pollution by smokestack effluents. They also have been used to measure deep-water currents in oceans and snow-water content in watersheds. Researchers in the biological sciences, too, have made use of radioactive tracers to study complex processes. For example, thousands of plant metabolic studies have been conducted on amino acids and compounds of sulfur, phosphorus, and nitrogen.